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PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BRPK; FLJ27236; PINK 1; PINK-1; protein kinase BRPK; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial
基因别名: 1190006F07Rik; AU042772; AW557854; BRPK; mFLJ00387; PARK6; PINK1
UniProt ID: (Human) Q9BXM7, (Mouse) Q99MQ3
Entrez Gene ID: (Human) 65018, (Mouse) 68943