Search Thermo Fisher Scientific
Immunogen sequence: SLCSEPLIEL CSSGASGSLF YVSSDDEFII KTVQHKEAEF LQKLLPGYYM NLNQNPRTLL PKFYGLYCVQ AGGKNIRIVV MNNLLPRSVK MHIKYDLKGS TYKRRASQKE REKPLPTFKD LDFLQDIPDG LFLDADMYNA LCKTLQRDCL VLQSFKIMDY SLLMSIHNID HAQREPLSSE TQYSVDTRRP APQKALYSTA MESIQGEARR GGTMETDDHM GGIPARNSKG ERLLLYIGII DILQSYRFVK KLEHSWKALV HDGDTVSVHR PGFYAERFQR FMCNTVFKKI PCVHLGRPDV LPQTPPLEEI SEGSPIPDPS FSPLVGETLQ MLTTSTTLEK LEVAESEFTH
PIP5K1A lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 alpha phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1 is required for Wnt3a-induced LRP6 phosphorylation at ser1490 in mammalian cells. Wnt3a stimulates the formation of phosphatidylinositol 4,5-bisphosphates through 'frizzled' and 'disheveled', the latter of which directly interacts with and activated PIP5KI. PIP5K1A-mediated PIP(2) production is crucial for HIV-1 entry and the early steps of infection in permissive lymphocytes. Overexpression of wild-type PI4P5K1A increases HIV-1 Env-mediated PIP(2) production and enhances viral replication in primary lymphocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha; Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Phosphatidylinositol 4-phosphate 5-kinase type I beta; Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase; phosphatidylinositol-4-phosphate 5-kinase type I alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PI4P5KIbeta; PI51A; PIP5K1-alpha; PIP5KIalpha; ptdIns(4)P-5-kinase 1 alpha
基因别名: PI4P5K-I[a]; PIP5K1-alpha; PIP5K1A; Pip5k1b; PIP5KIalpha; Pipk5a
UniProt ID: (Human) Q99755, (Mouse) P70182
Entrez Gene ID: (Human) 8394, (Mouse) 18720, (Rat) 365865
分子生物学功能: kinase