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PIP5K1A Antibody (PA5-106429) in IHC (P)
Immunohistochemistry analysis of PIP5K1A in rat heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PIP5K1A polyclonal antibody (Product # PA5-106429) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-106429
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PIP5K1A(Accession Q99755), corresponding to amino acid residues S11-I61.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854101
产品详细信息
Antibody detects endogenous levels of total PIP5K1A.
靶标信息
PIP5K1A lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 alpha phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1 is required for Wnt3a-induced LRP6 phosphorylation at ser1490 in mammalian cells. Wnt3a stimulates the formation of phosphatidylinositol 4,5-bisphosphates through 'frizzled' and 'disheveled', the latter of which directly interacts with and activated PIP5KI. PIP5K1A-mediated PIP(2) production is crucial for HIV-1 entry and the early steps of infection in permissive lymphocytes. Overexpression of wild-type PI4P5K1A increases HIV-1 Env-mediated PIP(2) production and enhances viral replication in primary lymphocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha; Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Phosphatidylinositol 4-phosphate 5-kinase type I beta; Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase; phosphatidylinositol-4-phosphate 5-kinase type I alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PI4P5KIbeta; PI51A; PIP5K1-alpha; PIP5KIalpha; ptdIns(4)P-5-kinase 1 alpha
基因别名: PI4P5K-I[a]; PIP5K1-alpha; PIP5K1A; Pip5k1b; PIP5KIalpha; Pipk5a
UniProt ID: (Human) Q99755, (Mouse) P70182
Entrez Gene ID: (Human) 8394, (Mouse) 18720, (Rat) 365865
1-phosphatidylinositol-3-phosphate 5-kinase activity
protein binding
ATP binding
1-phosphatidylinositol-4-phosphate 5-kinase activity
kinase binding
1-phosphatidylinositol-5-kinase activity
1-phosphatidylinositol-3-phosphate 4-kinase activity
phosphatidylinositol-3,4-bisphosphate 5-kinase activity
nucleotide binding
kinase activity
phosphatidylinositol phosphate kinase activity
transferase activity
kinase
glycerophospholipid metabolic process
phosphatidylinositol biosynthetic process
phagocytosis
signal transduction
phospholipid biosynthetic process
fibroblast migration
regulation of phosphatidylinositol 3-kinase signaling
cell migration
keratinocyte differentiation
actin cytoskeleton reorganization
phosphatidylinositol phosphorylation
focal adhesion assembly
cell chemotaxis
protein targeting to plasma membrane
activation of GTPase activity
ruffle assembly
phosphorylation
phosphatidylinositol metabolic process
