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Additional Information: This antibody is expected to recognize both reported isoforms (NP_001005242.2; NP_004563.2).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Plakophilin-2
基因别名: 1200008D14Rik; 1200012P04Rik; AA516617; ARVD9; PKP2; Pkp2l
UniProt ID: (Human) Q99959, (Mouse) Q9CQ73
Entrez Gene ID: (Human) 5318, (Mouse) 67451