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产品信息
PA5-40556
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human POU2F3
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2576626
产品详细信息
Peptide sequence: KMSGDVADST DARSTLSQVE PGNDRKGLDF NRQIKTEDLS DSLQQTLSHR
Sequence homology: Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 77%
靶标信息
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 11-Oct; Epoc-1; FLJ40063; MGC126698; Oct-11; Octamer-binding protein 11; Octamer-binding transcription factor 11; OTF-11; POU domain transcription factor OCT11a; POU domain, class 2, transcription factor 3; Rov 1 pou-homeodomain protein; Transcription factor PLA-1; Transcription factor Skn-1
基因别名: Epoc-1; Epoc1; OCT-11; Oct-11a; OCT11; OTF-11; OTF11; PLA-1; PLA1; POU2F3; Skin; Skin-1a; Skn-1; Skn-1a; Skn-li; Skn1
UniProt ID: (Human) Q9UKI9, (Rat) P42571, (Mouse) P31362
Entrez Gene ID: (Human) 25833, (Rat) 116544, (Mouse) 18988
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein dimerization activity
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
epidermis development
keratinocyte differentiation
wound healing
negative regulation by host of viral transcription
positive regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
