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Platelet Activating Factor (PAF) is a biologically active phospholipid, which exerts primarily proinflammatory activities by specifically signaling through G-protein-coupled receptors on platelets, neutrophils, and monocytes. Platelet Activating Factor Acetylhydrolase (PAF-AH) is a secreted protein that mediates PAF activity by specifically catalyzing hydrolysis of the "sn2" ester bond, resulting in the conversion of PAF to the biologically inactive lyso-PAF. PAF-AH can also interact with LDL particles to induce the hydrolysis of LDL-associated, oxidized phospholipids, generating lysophosphatidylcholine (lyso-PC) and other lysophospholipids.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; Group-VIIA phospholipase A2; gVIIA-PLA2; LDL-associated phospholipase A2; LDL-PLA(2); lipoprotein-associated phospholipase A2; PAF 2-acylhydrolase; PAF acetylhydrolase; phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma); Platelet-activating factor acetylhydrolase
基因别名: LDL-PLA2; LP-PLA2; PAFAD; PAFAH; PLA2G7
UniProt ID: (Human) Q13093
Entrez Gene ID: (Human) 7941