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Immunogen sequence: EERSASRTK QRAREWAKSM TSVLEPVLDL TYPVTSMFTG SAFNRSIHRV FQDKQIEDLW LPYFNVTTDI TASAMRVHKD GSLWRYVRAS MTLSGYLPPL CDPKDGHLLM DGGYINNLPA DIARSMGAKT VIAIDVGSQD ETDLSTYGDS LSGWWLLWKR LNPWADKVKV PDMAEIQSRL AYVSCVRQLE VVKSSSYCEY LRPPIDCFKT MDFGKFDQIY DVGYQYGKAV FGGWSRGNVI EKMLTDRRST DLNESRRADV LAFPSSGFTD LAEIVSRIEP PTSYVSDGCA DGEESDCLTE YEEDAGPDCS RDEGGSPEGA SPSTASEMEE EKSILRQRRC LPQEPPGSAT DA (977-1327 aa encoded by BC051768)
This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Neuropathy target esterase; patatin-like phospholipase domain containing 6; Patatin-like phospholipase domain-containing protein 6; Swiss cheese; Swiss-cheese
基因别名: AI661849; BNHS; iPLA2delta; LNMS; MSws; NTE; NTEMND; OMCS; PNPLA6; RGD1564611; SPG39; sws
UniProt ID: (Human) Q8IY17, (Mouse) Q3TRM4
Entrez Gene ID: (Human) 10908, (Mouse) 50767, (Rat) 360753
分子生物学功能:
esterase