Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
CL59414929100UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
激发/发射光谱
593/614 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Wet ice
靶标信息
POFUT1, an endoplasmic reticulum-residing member of the glycosyltransferase O-Fuc family, adds O-fucose through an O-glycosidic linkage to conserved serine or threonines in epidermal growth factor-like repeats of several cell surface and secreted proteins. Unlike its homolog POFUT2, POFUT1 can also catalyze the transfer of fucose to thrombospondin type 1 repeats. Many of the substrates of POFUT1 are involved in ligand-induced receptor signaling. One such protein is Notch; mouse ES cells lacking POFUT have normal levels of Notch receptors at the cell surface, but these receptors do not bind Notch ligands or exhibit Notch signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: GDP-fucose protein O-fucosyltransferase 1; o-fucosyltransferase protein; O-FucT-1; Peptide-O-fucosyltransferase 1; pofut1 {ECO:0000312|RGD:1303001}
基因别名: DDD2; FUT12; KIAA0180; mKIAA0180; O-Fuc-T; O-FucT-1; O-FUT; OFUCT1; POFUT1
UniProt ID: (Human) Q9H488, (Mouse) Q91ZW2, (Rat) Q6EV70
Entrez Gene ID: (Human) 23509, (Mouse) 140484, (Rat) 311551
angiogenesis
somitogenesis
fucose metabolic process
regulation of transcription, DNA-templated
protein O-linked glycosylation
Notch signaling pathway
nervous system development
heart development
embryo development
O-glycan processing
protein O-linked fucosylation
carbohydrate metabolic process
fucosylation
biological_process
