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产品信息
H00023509-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3H1
抗原
POFUT1 (NP_758436, 85 a.a. approximately 194 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: VSYQKYFKLE PLQAYHRVIS LEDFMEKLAP THWPPEKRVA YCFEVAAQRS PDKKTCPMKE GNPFGPFWDQ FHVSFNKSEL FTGISFSASY REQWSQRREN HSCVTLLFPR
靶标信息
POFUT1, an endoplasmic reticulum-residing member of the glycosyltransferase O-Fuc family, adds O-fucose through an O-glycosidic linkage to conserved serine or threonines in epidermal growth factor-like repeats of several cell surface and secreted proteins. Unlike its homolog POFUT2, POFUT1 can also catalyze the transfer of fucose to thrombospondin type 1 repeats. Many of the substrates of POFUT1 are involved in ligand-induced receptor signaling. One such protein is Notch; mouse ES cells lacking POFUT have normal levels of Notch receptors at the cell surface, but these receptors do not bind Notch ligands or exhibit Notch signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GDP-fucose protein O-fucosyltransferase 1; o-fucosyltransferase protein; O-FucT-1; Peptide-O-fucosyltransferase 1
基因别名: DDD2; FUT12; KIAA0180; O-Fuc-T; O-FucT-1; O-FUT; OFUCT1; POFUT1
UniProt ID: (Human) Q9H488
Entrez Gene ID: (Human) 23509
