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The paraoxonase (PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: A esterase 1; A-esterase 1; Aromatic esterase 1; arylesterase 1; arylesterase B-type; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; ESAesterase A; esterase A; K-45; paraoxonase B-type; PON 1; serum aryldiakylphosphatase; Serum aryldialkylphosphatase 1; Serum paraoxonase/arylesterase 1
基因别名: ESA; MVCD5; PON; PON1
UniProt ID: (Human) P27169, (Mouse) P52430, (Rat) P55159
Entrez Gene ID: (Human) 5444, (Mouse) 18979, (Rat) 84024