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产品信息
PTPA-BIOTIN
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 200-250 on human Serine / Threonine-Protein Phosphatase 2A Activator.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC2184; OTTHUMP00000022333; Phosphotyrosyl phosphatase activator; PP2A phosphatase activator; PP2A subunit B' isoform PR53; PP2A, subunit B', PR53 isoform; protein phosphatase 2 regulatory subunit 4; protein phosphatase 2A activator, regulatory subunit 4; protein phosphatase 2A regulatory subunit 4; protein phosphatase 2A, regulatory subunit B (PR 53); protein phosphatase 2A, regulatory subunit B' (PR 53); PTPA; Serine/threonine-protein phosphatase 2A activator; Serine/threonine-protein phosphatase 2A regulatory subunit 4; Serine/threonine-protein phosphatase 2A regulatory subunit B'
基因别名: 2610042B21Rik; C77440; N28142; PP2A; PPP2R4; PR53; PTPA
UniProt ID: (Human) Q15257, (Mouse) P58389
Entrez Gene ID: (Human) 5524, (Rat) 362102, (Mouse) 110854
peptidyl-prolyl cis-trans isomerase activity
receptor binding
protein binding
ATP binding
protein tyrosine phosphatase activator activity
protein phosphatase type 2A regulator activity
ATPase activity
protein homodimerization activity
protein heterodimerization activity
protein phosphatase 2A binding
nucleotide binding
isomerase activity
phosphatase activator activity
protein-binding activity modulator
phosphatase activator
phosphatase modulator
protein peptidyl-prolyl isomerization
mitotic spindle organization in nucleus
negative regulation of phosphoprotein phosphatase activity
positive regulation of phosphoprotein phosphatase activity
regulation of protein phosphatase type 2A activity
positive regulation of protein dephosphorylation
negative regulation of protein dephosphorylation
positive regulation of apoptotic process
regulation of phosphoprotein phosphatase activity
metabolic process
positive regulation of catalytic activity
