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Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide(NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. PPAPDC1A is preferentially expressed in endothelial cells. Studies of PPAPDC1A and PAP activity suggest that they may play a role in angiogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: diacylglycerol pyrophosphate like 2; diacylglycerol pyrophosphate phosphatase-like 2; phosphatidate phosphatase PPAPDC1A; phosphatidic acid phosphatase type 2 domain containing 1A; Phosphatidic acid phosphatase type 2 domain-containing protein 1A; Phospholipid phosphatase 4; RP11-257O17.1
基因别名: C030048B12Rik; DPPL2; Gm1090; PLPP4; PPAPDC1; PPAPDC1A
UniProt ID: (Human) Q5VZY2, (Mouse) Q0VBU9
Entrez Gene ID: (Human) 196051, (Mouse) 381925
分子生物学功能:
phosphatase