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产品信息
CL55560127100UL
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
4E12F10
偶联物
激发/发射光谱
555/570 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Wet ice
靶标信息
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HUMPPARG; Nuclear receptor subfamily 1 group C member 3; OTTHUMP00000185032; OTTHUMP00000185036; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator-activated nuclear receptor gamma variant 1; Peroxisome proliferator-activated receptor gamma; PPAR gamma; PPAR-gamma; PPARy
基因别名: CIMT1; GLM1; NR1C3; PPARG; PPARG1; PPARG2; PPARgamma
UniProt ID: (Human) P37231
Entrez Gene ID: (Human) 5468
core promoter sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
prostaglandin receptor activity
protein binding
transcription factor binding
drug binding
zinc ion binding
enzyme binding
protein phosphatase binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
activating transcription factor binding
identical protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
retinoid X receptor binding
arachidonic acid binding
alpha-actinin binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
placenta development
negative regulation of acute inflammatory response
transcription initiation from RNA polymerase II promoter
lipid metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
G-protein coupled receptor signaling pathway
heart development
response to nutrient
regulation of blood pressure
response to cold
response to mechanical stimulus
macrophage derived foam cell differentiation
negative regulation of macrophage derived foam cell differentiation
negative regulation of receptor biosynthetic process
negative regulation of cholesterol storage
negative regulation of sequestering of triglyceride
long-chain fatty acid transport
fatty acid oxidation
monocyte differentiation
negative regulation of cell growth
epithelial cell differentiation
response to caffeine
organ regeneration
response to retinoic acid
cellular response to insulin stimulus
negative regulation of collagen biosynthetic process
response to vitamin A
response to lipid
peroxisome proliferator activated receptor signaling pathway
response to immobilization stress
response to diuretic
glucose homeostasis
response to starvation
regulation of circadian rhythm
lipoprotein transport
steroid hormone mediated signaling pathway
response to estrogen
innate immune response
cell fate commitment
positive regulation of fat cell differentiation
low-density lipoprotein particle receptor biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
cell maturation
rhythmic process
negative regulation of smooth muscle cell proliferation
positive regulation of oligodendrocyte differentiation
white fat cell differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of telomerase activity
lipid homeostasis
response to low-density lipoprotein particle
positive regulation of phagocytosis, engulfment
negative regulation of interferon-gamma-mediated signaling pathway
regulation of cholesterol transporter activity
regulation of transcription involved in cell fate commitment
cellular response to retinoic acid
cellular response to vitamin E
cellular response to prostaglandin E stimulus
cellular response to hyperoxia
response to metformin
negative regulation of pancreatic stellate cell proliferation
