Proteintech

PPAR Gamma Monoclonal Antibody (4E12F10), CoraLite® Plus 647

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说明书
实验方案
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产品信息

CL647-60127

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

0.2 µg/1x10^6 cell suspension
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

4E12F10

抗原

Recombinant protein
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偶联物

CoraLite® Plus 647 CoraLite® Plus 647 CoraLite® Plus 647

激发/发射光谱

654/674 nm

形式

Liquid

纯化类型

Protein G

保存液

PBS with 50% glycerol, 0.5% BSA

内含物

0.05% ProClin 300

保存条件

-20° C, store in dark

运输条件

Wet ice

产品详细信息

Immunogen sequence: NKCQYCRFQK CLAVGMSHNA IRFGRMPQAE KEKLLAEISS DIDQLNPESA DLRALAKHLY DSYIKSFPLT KAKARAILTG KTTDKSPFVI YDMNSLMMGE DKIKFKHITP LQEQSKEVAI RIFQGCQFRS VEAVQEITEY AKSIPGFVNL DLNDQVTLLK YGVHEIIYTM LASLMNKDGV LISEGQGFMT REFLKSLRKP FGDFMEPKFE FAVKFNALEL DDSDLAIFIA VIILSGDRPG LLNVKPIEDI QDNLLQALEL QLKLNHPESS QLFAKLLQKM TDLRQIVTEH VQLLQVIKKT ETDMSLHPLL QEIYKDLY

靶标信息

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HUMPPARG; Nuclear receptor subfamily 1 group C member 3; OTTHUMP00000185032; OTTHUMP00000185036; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor gamma 2; peroxisome proliferator activated receptor gamma 4; peroxisome proliferator activator receptor, gamma; peroxisome proliferator-activated nuclear receptor gamma variant 1; Peroxisome proliferator-activated receptor gamma; PPAR gamma; PPAR-gamma; PPARy

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基因别名: CIMT1; GLM1; NR1C3; PPAR-gamma; PPAR-gamma2; PPARG; PPARG1; PPARG2; PPARgamma; PPARgamma2

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UniProt ID: (Human) P37231, (Mouse) P37238, (Rat) O88275

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Entrez Gene ID: (Human) 5468, (Mouse) 19016, (Rat) 25664

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功能
core promoter sequence-specific DNA binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding prostaglandin receptor activity protein binding transcription factor binding drug binding zinc ion binding enzyme binding protein phosphatase binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity activating transcription factor binding identical protein binding sequence-specific DNA binding transcription regulatory region DNA binding retinoid X receptor binding arachidonic acid binding alpha-actinin binding RNA polymerase II regulatory region DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding metal ion binding WW domain binding C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
参与通路
negative regulation of transcription from RNA polymerase II promoter placenta development negative regulation of acute inflammatory response transcription initiation from RNA polymerase II promoter lipid metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction G-protein coupled receptor signaling pathway heart development response to nutrient regulation of blood pressure response to cold response to mechanical stimulus macrophage derived foam cell differentiation negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride long-chain fatty acid transport fatty acid oxidation monocyte differentiation negative regulation of cell growth epithelial cell differentiation response to caffeine organ regeneration response to retinoic acid cellular response to insulin stimulus negative regulation of collagen biosynthetic process response to vitamin A response to lipid peroxisome proliferator activated receptor signaling pathway response to immobilization stress response to diuretic glucose homeostasis response to starvation regulation of circadian rhythm lipoprotein transport steroid hormone mediated signaling pathway response to estrogen innate immune response cell fate commitment positive regulation of fat cell differentiation low-density lipoprotein particle receptor biosynthetic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation cell maturation rhythmic process negative regulation of smooth muscle cell proliferation positive regulation of oligodendrocyte differentiation white fat cell differentiation positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of telomerase activity lipid homeostasis response to low-density lipoprotein particle positive regulation of phagocytosis, engulfment negative regulation of interferon-gamma-mediated signaling pathway regulation of cholesterol transporter activity regulation of transcription involved in cell fate commitment cellular response to retinoic acid cellular response to vitamin E cellular response to prostaglandin E stimulus cellular response to hyperoxia response to metformin negative regulation of pancreatic stellate cell proliferation negative regulation of cytokine production response to dietary excess diet induced thermogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response negative regulation of cell proliferation response to light stimulus regulation of gene expression regulation of lipid metabolic process intracellular receptor signaling pathway response to food positive regulation of apoptotic process fat cell differentiation regulation of fat cell differentiation brown fat cell differentiation cellular response to lithium ion cellular response to organic cyclic compound negative regulation of peptide hormone secretion negative regulation of cellular response to insulin stimulus fatty acid metabolic process response to organic substance response to organic cyclic compound response to drug cellular response to prostaglandin stimulus
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