OriGene

PPARD Monoclonal Antibody (OTI2D2), TrueMAB™

查看其他14个PPAR delta抗体
说明书
实验方案
技术支持
说明书
实验方案
技术支持

产品信息

TA811236

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

OTI2D2

抗原

Human recombinant protein fragment corresponding to amino acids 1-244 of human PPARD produced in E.coli.
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 1% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: MGC3931; NUC1; NUCI; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; PPARdelta/beta

查看更多 收起

基因别名: FAAR; NR1C2; NUC-1; NUC1; NUCI; NUCII; PPAR-beta; PPAR-delta; PPAR[b]; PPARB; Pparb/d; PPARD; PPARdelta

查看更多 收起

UniProt ID: (Human) Q03181, (Mouse) P35396

查看更多 收起

Entrez Gene ID: (Human) 5467, (Mouse) 19015

查看更多 收起

功能
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding transcription factor binding drug binding zinc ion binding lipid binding sequence-specific DNA binding protein heterodimerization activity NF-kappaB binding linoleic acid binding fatty acid binding enzyme activator activity prostacyclin receptor activity metal ion binding retinoid X receptor binding C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
参与通路
negative regulation of transcription from RNA polymerase II promoter glucose metabolic process proteoglycan metabolic process generation of precursor metabolites and energy regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter lipid metabolic process fatty acid beta-oxidation vitamin A metabolic process apoptotic process heart development embryo implantation cholesterol metabolic process cell proliferation axon ensheathment phospholipid biosynthetic process fatty acid catabolic process mRNA transcription response to glucose positive regulation of phosphatidylinositol 3-kinase signaling response to activity regulation of skeletal muscle satellite cell proliferation negative regulation of smooth muscle cell migration glucose transport fatty acid transport cell differentiation negative regulation of cell growth intracellular receptor signaling pathway cell-substrate adhesion positive regulation of insulin secretion negative regulation of collagen biosynthetic process response to vitamin A wound healing negative regulation of apoptotic process steroid hormone mediated signaling pathway positive regulation of skeletal muscle tissue regeneration keratinocyte proliferation positive regulation of fat cell differentiation negative regulation of myoblast differentiation positive regulation of epidermis development negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of vasodilation decidualization negative regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation negative regulation of inflammatory response keratinocyte migration adipose tissue development cellular response to lipopolysaccharide cellular response to hypoxia apoptotic signaling pathway negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of myoblast proliferation placenta development transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter G-protein coupled receptor signaling pathway positive regulation of cell proliferation epidermis development cellular process fatty acid oxidation regulation of cell proliferation anagen positive regulation of catalytic activity regulation of fat cell differentiation regulation of insulin secretion
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持