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OriGene
PPIF Monoclonal Antibody (OTI4D3), TrueMAB™
高级验证
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
图: 1 / 3
PPIF Antibody (CF809066) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPIF (RC223397, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PPIF. (1. Positive lysates LY417109 (100 µg) and LC417109 (20 µg) can be purchased separately from OriGene.
产品信息
CF809066
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI4D3
抗原
Full length human recombinant protein of human PPIF produced in E.coli.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cyclophilin 3; Cyclophilin D; Cyclophilin F; CyP-D; CyP-M; Mitochondrial cyclophilin; mitochondrial Cyclophilin D; mitochondrial peptidyl-prolyl cis-trans isomerase; Peptidyl-prolyl cis-trans isomerase F; Peptidyl-prolyl cis-trans isomerase F, mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; PPIase F; Rotamase F
基因别名: AW457192; CyP-D; CyP-F; CyP-M; CYP3; CypD; PPIase; PPIF
UniProt ID: (Human) P30405, (Rat) P29117, (Mouse) Q99KR7
Entrez Gene ID: (Human) 10105, (Rat) 282819, (Mouse) 105675
protein peptidyl-prolyl isomerization
response to ischemia
protein folding
apoptotic mitochondrial changes
regulation of proton-transporting ATPase activity, rotational mechanism
regulation of necrotic cell death
negative regulation of ATPase activity
negative regulation of apoptotic process
regulation of mitochondrial membrane permeability
necroptotic process
cellular response to hydrogen peroxide
cellular response to arsenic-containing substance
cellular response to calcium ion
positive regulation of release of cytochrome c from mitochondria
negative regulation of release of cytochrome c from mitochondria
negative regulation of oxidative phosphorylation
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
negative regulation of oxidative phosphorylation uncoupler activity
negative regulation of intrinsic apoptotic signaling pathway
response to oxidative stress
regulation of apoptotic process
apoptotic process
programmed cell death
