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产品信息
MA5-30780
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
07
抗原
Recombinant Human PPM1A/PP2C-alpha protein (Met1-Trp382)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2786463
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human PPM1A/PP2C-alpha.
靶标信息
PPM1A (Protein phosphatase 1A) is also named as PPPM1A and belongs to the PP2C family. It is a serine/threonine protein phosphatase that is essential for regulating cellular stress responses in eukaryotes. PPM1A plays an important role in tumor suppression and that it negatively controls many signaling pathways which are critical for trophoblast invasion. This protein distributes in both the cytoplasm and nucleus of mammalian cells. It has 2 isoforms produced by alternative splicing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PP2C-alpha; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; protein phosphatase, Mg2+/Mn2+ dependent, 1A
基因别名: PP2C-ALPHA; PP2CA; PP2Calpha; PPM1A; PPPM1A
UniProt ID: (Human) P35813
Entrez Gene ID: (Human) 5494
negative regulation of transcription from RNA polymerase II promoter
protein dephosphorylation
N-terminal protein myristoylation
cell cycle arrest
negative regulation of SMAD protein complex assembly
Wnt signaling pathway
dephosphorylation
positive regulation of Wnt signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
peptidyl-threonine dephosphorylation
negative regulation of NF-kappaB import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription, DNA-templated
positive regulation of protein export from nucleus
cellular response to transforming growth factor beta stimulus
