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Immunogen sequence: EEEEDDDEE KAPVTLLDAQ SLAQSFFNRL WEVAGQWQKQ VPLAARASQR QWLVSIHAIR NTRRKMEDRH VSLPSFNQLF GLSDPVNRAY FAVFDGHGGV DAARYAAVHV HTNAARQPEL PTDPEGALRE AFRRTDQMFL RKAKRERLQS GTTGVCALIA GATLHVAWLG DSQVILVQQG QVVKLMEPHR PERQDEKARI EALGGFVSHM DCWRVNGTLA VSRAIGDVFQ KPYVSGEADA ASRALTGSED YLLLACDGFF DVVPHQEVVG LVQSHLTRQQ GSGLRVAEEL VAAARERGSH DNITVMVVFL RDPQELLEGG NQGEGDPQAE GRRQDLPSSL PEPETQAPPR S (104-453 aa encoded by BC071989)
PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Ca(2+)/calmodulin-dependent protein kinase phosphatase; calcium/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; hFem-2; Partner of PIX 2; partner of PIX2; PP2C phosphatase; Protein fem-2 homolog; Protein phosphatase 1F; protein phosphatase 1F (PP2C domain containing); protein phosphatase, Mg2+/Mn2+ dependent, 1F
基因别名: 1110021B16Rik; 4933427B07Rik; CAMKP; CaMKPase; FEM-2; hFEM-2; KIAA0015; mKIAA0015; POPX2; PPM1F
UniProt ID: (Human) P49593, (Mouse) Q8CGA0, (Rat) Q9WVR7
Entrez Gene ID: (Human) 9647, (Mouse) 68606, (Rat) 287931
分子生物学功能: protein phosphatase