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产品信息
18801-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide
偶联物
形式
Liquid
浓度
0.14 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
Neurabin I is a brain-specific protein which contains an F-actin binding domain, a PDZ domain, a transmembrane-protein-interacting-domain, and a coiled-coil region. As its structure suggests, neurabin I is a promiscuous protein binding to F-actin, protein phosphatase 1, TGN38, and p70 S6 kinase. Found exclusively in brain, this protein is highly concentrated in the synapse and has also been shown to be enriched in the lamellipodia of the growth cone during neuronal development. Neurabin I appears to be a bridging protein by targeting other proteins to the synapse or by linking membrane proteins to the actin cytoskeleton.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: actin-binding protein neurabin; neurabin 1; Neurabin I; Neurabin-1; Neurabin-I; neural tissue-specific F-actin binding protein; Neural tissue-specific F-actin-binding protein I; p180; PP1bp175; Protein phosphatase 1 regulatory subunit 9A; protein phosphatase 1, regulatory (inhibitor) subunit 9A; protein phosphatase 1, regulatory subunit 9A
基因别名: 2810430P21Rik; 4930518N04Rik; 5330407E15; A230094E16Rik; BB181831; KIAA1222; mKIAA1222; Neb1; Neurabin-I; NRB; NRB1; NRBI; PPP1R9A
UniProt ID: (Human) Q9ULJ8, (Rat) O35867
Entrez Gene ID: (Human) 55607, (Mouse) 243725, (Rat) 84685
actin filament organization
positive regulation of neuron projection development
calcium-mediated signaling
neuron projection development
positive regulation of protein kinase activity
negative regulation of synaptic transmission
regulation of filopodium assembly
negative regulation of stress fiber assembly
positive regulation of dendritic spine development
cellular response to toxic substance
negative regulation of long-term synaptic potentiation
positive regulation of long term synaptic depression
aging
regulation of actin filament polymerization
regulation of synapse structural plasticity
regulation of synapse assembly
excitatory postsynaptic potential
regulation of dendritic spine morphogenesis
negative regulation of spontaneous neurotransmitter secretion
