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产品信息
13123-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PPP2R2B Fusion Protein Ag3860 (100-443 aa encoded by BC031790)
偶联物
Unconjugated
形式
Liquid
浓度
0.14 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: QQNAAYFLL STNDKTVKLW KVSERDKRPE GYNLKDEEGR LRDPATITTL RVPVLRPMDL MVEATPRRVF ANAHTYHINS ISVNSDYETY MSADDLRINL WNFEITNQSF NIVDIKPANM EELTEVITAA EFHPHHCNTF VYSSSKGTIR LCDMRASALC DRHTKFFEEP EDPSNRSFFS EIISSISDVK FSHSGRYIMT RDYLTVKVWD LNMENRPIET YQVHDYLRSK LCSLYENDCI FDKFECVWNG SDSVIMTGSY NNFFRMFDRN TKRDVTLEAS RENSKPRAIL KPRKVCVGGK RRKDEISVDS LDFSKKILHT AWHPSENIIA VAATNNLYIF QDKVN (100-443 aa encoded by BC031790)
靶标信息
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BRbeta B-regulatory subunit of protein phosphatase 2A; PP2A PP2ABBETA; PP2A subunit B isoform B55-beta; PP2A subunit B isoform beta; PP2A subunit B isoform BRB; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A, subunit B, B-beta isoform; PP2A, subunit B, B55-beta isoform; PP2A, subunit B, BRB isoform; PP2A, subunit B, PR55-beta isoform; PP2A, subunit B, R2-beta isoform; PR2A PR2ABBETA; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform; protein phosphatase 2 regulatory subunit B, beta; protein phosphatase 2, regulatory subunit B, beta; serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform; serine/threonine protein phosphatase 2A, neuronal isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
基因别名: 2900026H06Rik; 6330404L05Rik; B55BETA; E130009M08Rik; PP2A-PR55B; PP2AB55BETA; PP2ABBETA; PP2APR55B; PP2APR55BETA; PPP2R2B; Pppr2b2; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B; PR55-BETA; PR55BETA; SCA12
UniProt ID: (Human) Q00005, (Rat) P36877, (Mouse) Q6ZWR4
Entrez Gene ID: (Human) 5521, (Rat) 60660, (Mouse) 72930
apoptotic process
regulation of protein phosphatase type 2A activity
mitochondrial fission
protein targeting to mitochondrion
signal transduction
spermatid development
brain development
neuron differentiation
positive regulation of neuron apoptotic process
mitochondrial fragmentation involved in apoptotic process
