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PPP3CA Antibody (TA810584) in IHC (P)
Immunohistochemical staining of paraffin-embedded human embryonic cerebellum within the normal limits using anti-PPP3CA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA810584)(1:2000)
产品信息
TA810584
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI5C6
抗原
Human recombinant protein fragment corresponding to amino acids 2-105 of human PPP3CA produced in E.coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcineurin A alpha; Calcineurin subunit A alpha; CalcineurinA; Calmodulin-dependent calcineurin A subunit alpha isoform; CALNA 1; CAM-PRP catalytic subunit; CCN 1; CNA alpha; PP2CB; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; Protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 catalytic subunit alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase-2Ba; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
基因别名: CALN; CALNA; CALNA1; CCN1; CNA; CNA1; PPP2B; PPP3CA
UniProt ID: (Human) Q08209, (Rat) P63329
Entrez Gene ID: (Human) 5530, (Rat) 24674
protein serine/threonine phosphatase activity
calcium ion binding
protein binding
calmodulin binding
drug binding
enzyme binding
calmodulin-dependent protein phosphatase activity
protein heterodimerization activity
protein dimerization activity
phosphoprotein phosphatase activity
calcium-dependent protein serine/threonine phosphatase activity
metal ion binding
protein phosphatase
G1/S transition of mitotic cell cycle
response to amphetamine
protein dephosphorylation
protein import into nucleus
calcium ion transport
Wnt signaling pathway, calcium modulating pathway
transition between fast and slow fiber
cardiac muscle hypertrophy in response to stress
dephosphorylation
calcineurin-NFAT signaling cascade
multicellular organismal response to stress
negative regulation of chromatin binding
cellular response to drug
Fc-epsilon receptor signaling pathway
T cell activation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin secretion
skeletal muscle fiber development
negative regulation of dendrite morphogenesis
modulation of synaptic transmission
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NFAT protein import into nucleus
response to calcium ion
excitatory postsynaptic potential
cellular response to glucose stimulus
positive regulation of cardiac muscle hypertrophy in response to stress
calcium-mediated signaling
negative regulation of calcium ion-dependent exocytosis
