Loading ...

Proteintech

PPP6C Polyclonal Antibody

7 篇参考文献

查看其他10个PPP6C抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (7)

Application

PPP6C Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 7

PPP6C Antibody (15852-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using (Product # 15852-1-AP) (PPP6C antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

PPP6C Antibody in Immunoprecipitation (IP)

Product Image Gallery

产品信息

15852-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:200

免疫沉淀 (IP)

0.5-4.0 µg

查看3篇已发表文章 3篇已发表文章

不适用 (N/A)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

PPP6C Fusion Protein Ag8670 (1-305 aa encoded by BC006990)

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.13 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MAPLDLDKY VEIARLCKYL PENDLKRLCD YVCDLLLEES NVQPVSTPVT VCGDIHGQFY DLCELFRTGG QVPDTNYIFM GDFVDRGYYS LETFTYLLAL KAKWPDRITL LRGNHESRQI TQVYGFYDEC QTKYGNANAW RYCTKVFDML TVAALIDEQI LCVHGGLSPD IKTLDQIRTI ERNQEIPHKG AFCDLVWSDP EDVDTWAISP RGAGWLFGAK VTNEFVHINN LKLICRAHQL VHEGYKFMFD EKLVTVWSAP NYCYRCGNIA SIMVFKDVNT REPKLFRAVP DSERVIPPRT TTPYFL (1-305 aa encoded by B C006990)

靶标信息

Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5' to 3' exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5' and 3' overhang processing in nonhomologous DNA end joining.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIP_L to promote TNFα-mediated cell death.

Cell death & disease

Wu G,Li D,Liang W,Sun W,Xie X,Tong Y,Shan B,Zhang M,Lu X,Yuan J,Li Y

Wed Sep 07 00:00:00 UTC 2022

PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIP_L to promote TNFα-mediated cell death.

Cell death & disease

Wu G,Li D,Liang W,Sun W,Xie X,Tong Y,Shan B,Zhang M,Lu X,Yuan J,Li Y

Wed Sep 07 00:00:00 UTC 2022

Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha.

Molecular cell

Zhou Q,Hao B,Cao X,Gao L,Yu Z,Zhao Y,Zhu M,Zhong G,Chi F,Dai X,Mao J,Zhu Y,Rong P,Chen L,Bai X,Ye C,Chen S,Liang T,Li L,Feng XH,Tan M,Zhao B

Thu Dec 15 00:00:00 UTC 2022

Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha.

Molecular cell

Zhou Q,Hao B,Cao X,Gao L,Yu Z,Zhao Y,Zhu M,Zhong G,Chi F,Dai X,Mao J,Zhu Y,Rong P,Chen L,Bai X,Ye C,Chen S,Liang T,Li L,Feng XH,Tan M,Zhao B

Thu Dec 15 00:00:00 UTC 2022

Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha.

Molecular cell

Zhou Q,Hao B,Cao X,Gao L,Yu Z,Zhao Y,Zhu M,Zhong G,Chi F,Dai X,Mao J,Zhu Y,Rong P,Chen L,Bai X,Ye C,Chen S,Liang T,Li L,Feng XH,Tan M,Zhao B

Thu Dec 15 00:00:00 UTC 2022

Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha.

Molecular cell

Zhou Q,Hao B,Cao X,Gao L,Yu Z,Zhao Y,Zhu M,Zhong G,Chi F,Dai X,Mao J,Zhu Y,Rong P,Chen L,Bai X,Ye C,Chen S,Liang T,Li L,Feng XH,Tan M,Zhao B

Thu Dec 15 00:00:00 UTC 2022

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.

Protein & cell

Li M,Shu HB

Sat Aug 01 00:00:00 UTC 2020

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.

Protein & cell

Li M,Shu HB

Sat Aug 01 00:00:00 UTC 2020

Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.

The Journal of biological chemistry

Hwang J,Lee JA,Pallas DC

Fri Sep 30 00:00:00 UTC 2016

生物信息学

蛋白别名: ANKRD33; FLJ34236; PP-V; PP6C; protein phosphatase 6, catalytic subunit; Protein phosphatase V; serine/threonine protein phosphatase catalytic subunit; Serine/threonine-protein phosphatase 6 catalytic subunit; UNQ5837

基因别名: 2310003C10Rik; PP6; PP6C; PPP6; PPP6C; Ppv

UniProt ID: (Human) O00743, (Rat) Q64620, (Mouse) Q9CQR6

Entrez Gene ID: (Human) 5537, (Rat) 171121, (Mouse) 67857

功能

protein serine/threonine phosphatase activity protein binding metal ion binding phosphoprotein phosphatase activity hydrolase activity protein phosphatase

参与通路

G1/S transition of mitotic cell cycle protein dephosphorylation COPII vesicle coating cell cycle