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产品信息
PA1-30275
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 316-347 amino acids from the C-terminal region of human PRMT1
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1959925
产品详细信息
PA1-30275 detects PRMT1 from human samples.
靶标信息
PRMT1 is a member of the protein arginine N-methyltransferase (PRMT) family. Arginine methylation is an irreversible post translational modification which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These proteins include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Increased expression of PRMT1 may play a role in various types of cancer.
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生物信息学
蛋白别名: heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; Histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; Interferon receptor 1-bound protein 4; Protein arginine N-methyltransferase 1
基因别名: ANM1; HCP1; HMT2; HRMT1L2; IR1B4; PRMT1
UniProt ID: (Human) Q99873
Entrez Gene ID: (Human) 3276
protein binding
methyltransferase activity
N-methyltransferase activity
protein methyltransferase activity
methyl-CpG binding
protein-arginine N-methyltransferase activity
enzyme binding
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
identical protein binding
histone methyltransferase activity (H4-R3 specific)
poly(A) RNA binding
mitogen-activated protein kinase p38 binding
protein modifying enzyme
regulation of transcription, DNA-templated
protein methylation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell surface receptor signaling pathway
histone methylation
peptidyl-arginine methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
neuron projection development
histone H4-R3 methylation
positive regulation of erythrocyte differentiation
negative regulation of megakaryocyte differentiation
positive regulation of hemoglobin biosynthetic process
positive regulation of p38MAPK cascade
