Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 2
PRMT4 Antibody (PA5-78328) in IHC (P)
PRMT4 Polyclonal Antibody detects CARM1 protein on human breast cancer by immunohistochemical analysis. Sample: Paraffin-embedded breast cancer. PRMT4 Polyclonal Antibody (Product # PA5-78328) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-78328
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human CARM1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2736457
产品详细信息
Predicted Reactivity: Mouse (100%), Rat (100%), Zebrafish (94%), Xenopus laevis (91%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in DNA packaging, transcription regulation, signal transduction, mRNA stability, metabolism of nascent pre-RNA, and transcriptional activation. Tissue specificity: Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Coactivator-associated arginine methyltransferase 1; Histone-arginine methyltransferase CARM1; Protein arginine N-methyltransferase 4
基因别名: CARM1; PRMT4
UniProt ID: (Human) Q86X55
Entrez Gene ID: (Human) 10498
transcription coactivator activity
protein binding
beta-catenin binding
protein methyltransferase activity
histone-arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
ligand-dependent nuclear receptor transcription coactivator activity
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity (H3-R17 specific)
histone methyltransferase activity
protein homodimerization activity
transcription regulatory region DNA binding
lysine-acetylated histone binding
protein modifying enzyme
regulation of growth plate cartilage chondrocyte proliferation
transcription, DNA-templated
regulation of transcription, DNA-templated
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
aging
positive regulation of cell proliferation
viral process
histone methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
intracellular estrogen receptor signaling pathway
negative regulation of protein binding
regulation of intracellular estrogen receptor signaling pathway
histone H3-R2 methylation
histone H3-R17 methylation
cellular lipid metabolic process
positive regulation of fat cell differentiation
response to cAMP
endochondral bone morphogenesis
regulation of mRNA binding
negative regulation of dendrite development
