Proteintech

PRPS1 Polyclonal Antibody

PRPS1 Antibody in Immunocytochemistry (ICC/IF)

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PRPS1 Antibody (15549-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using PRPS1 antibody 15549-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

PRPS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PRPS1 Antibody in Immunoprecipitation (IP)

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产品信息

15549-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看8篇已发表文章 8篇已发表文章

免疫组化 (IHC)

查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:10-1:100

查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

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其他PubMed (Misc)

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不适用 (N/A)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

PRPS1 Fusion Protein Ag7907 (1-318 aa encoded by BC001605)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.23 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MPNIKIFSG SSHQDLSQKI ADRLGLELGK VVTKKFSNQE TCVEIGESVR GEDVYIVQSG CGEINDNLME LLIMINACKI ASASRVTAVI PCFPYARQDK KDKSRAPISA KLVANMLSVA GADHIITMDL HASQIQGFFD IPVDNLYAEP AVLKWIRENI SEWRNCTIVS PDAGGAKRVT SIADRLNVDF ALIHKERKKA NEVDRMVLVG DVKDRVAILV DDMADTCGTI CHAADKLLSA GATRVYAILT HGIFSGPAIS RINNACFEAV VVTNTIPQED KMKHCSKIQV IDISMILAEA IRRTHNGESV SYLFSHVPL (1-318 aa encoded by BC001605 )

靶标信息

This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Direct stimulation of de novo nucleotide synthesis by O-GlcNAcylation.

Nature chemical biology

Chen L,Zhou Q,Zhang P,Tan W,Li Y,Xu Z,Ma J,Kupfer GM,Pei Y,Song Q,Pei H

Mon Jan 01 00:00:00 EST 2024

Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation.

Cellular and molecular life sciences : CMLS

Chang CC,Peng M,Zhong J,Zhang Z,Keppeke GD,Sung LY,Liu JL

Thu Jul 14 00:00:00 EDT 2022

NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.

Frontiers in immunology

Xiong G,Feng Y,Yi X,Zhang X,Li X,Yang L,Yi Z,Sai B,Yang Z,Zhang Q,Kuang Y,Zhu Y

Mon Oct 10 00:00:00 EDT 2022

NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.

Frontiers in immunology

Xiong G,Feng Y,Yi X,Zhang X,Li X,Yang L,Yi Z,Sai B,Yang Z,Zhang Q,Kuang Y,Zhu Y

Mon Oct 10 00:00:00 EDT 2022

Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress.

Nature communications

Yang R,Yang C,Ma L,Zhao Y,Guo Z,Niu J,Chu Q,Ma Y,Li B

Thu Nov 17 00:00:00 EST 2022

Mitochondrial NADP⁺ is essential for proline biosynthesis during cell growth.

Nature metabolism

Tran DH,Kesavan R,Rion H,Soflaee MH,Solmonson A,Bezwada D,Vu HS,Cai F,Phillips JA,DeBerardinis RJ,Hoxhaj G

Thu Apr 01 00:00:00 EDT 2021

Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production.

Frontiers in cell and developmental biology

Chen X,Wu M,Liang N,Lu J,Qu S,Chen H

Wed Apr 21 00:00:00 EDT 2021

Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production.

Frontiers in cell and developmental biology

Chen X,Wu M,Liang N,Lu J,Qu S,Chen H

Wed Apr 21 00:00:00 EDT 2021

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.

Science advances

Srivastava S,Sahu U,Zhou Y,Hogan AK,Sathyan KM,Bodner J,Huang J,Wong KA,Khalatyan N,Savas JN,Ntziachristos P,Ben-Sahra I,Foltz DR

Fri Jan 01 00:00:00 EST 2021

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.

Science advances

Srivastava S,Sahu U,Zhou Y,Hogan AK,Sathyan KM,Bodner J,Huang J,Wong KA,Khalatyan N,Savas JN,Ntziachristos P,Ben-Sahra I,Foltz DR

Fri Jan 01 00:00:00 EST 2021

Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.

The Journal of investigative dermatology

Gu Z,Zhang H,Guo X,Cao Y

Sat Aug 01 00:00:00 EDT 2020

CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.

Oncotarget

Gu Z,Zhang H,Li Y,Shen S,Yin X,Zhang W,Cheng R,Zhang Y,Zhang X,Chen H,Huang B,Cao Y

Tue Dec 26 00:00:00 EST 2017

CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.

Oncotarget

Gu Z,Zhang H,Li Y,Shen S,Yin X,Zhang W,Cheng R,Zhang Y,Zhang X,Chen H,Huang B,Cao Y

Tue Dec 26 00:00:00 EST 2017

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Science (New York, N.Y.)

Ben-Sahra I,Hoxhaj G,Ricoult SJH,Asara JM,Manning BD

Fri Feb 12 00:00:00 EST 2016

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Science (New York, N.Y.)

Ben-Sahra I,Hoxhaj G,Ricoult SJH,Asara JM,Manning BD

Fri Feb 12 00:00:00 EST 2016

Quantitative proteomic dissection of a native 14-3-3ε interacting protein complex associated with hepatocellular carcinoma.

Amino acids

Bai C,Tang S,Bai C,Chen X

Tue Apr 01 00:00:00 EDT 2014

Quantitative proteomic dissection of a native 14-3-3ε interacting protein complex associated with hepatocellular carcinoma.

Amino acids

Bai C,Tang S,Bai C,Chen X

Tue Apr 01 00:00:00 EDT 2014

生物信息学

蛋白别名: deafness 2, perceptive, congenital; deafness, X-linked 2, perceptive, congenital; dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1); Phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase I; PPRibP; PRS-I; ribose-phosphate diphosphokinase 1; Ribose-phosphate pyrophosphokinase 1

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基因别名: 2310010D17Rik; ARTS; C76571; C76678; CMTX5; DFN2; DFNX1; PPRibP; Prps-1; PRPS1; PRS-I; PRSI

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UniProt ID: (Human) P60891, (Mouse) Q9D7G0, (Rat) P60892

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Entrez Gene ID: (Human) 5631, (Mouse) 19139, (Rat) 29562

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功能