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产品信息
PA1-4667
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the N-terminal region of rat DLG4 conjugated to KLH
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2277305
产品详细信息
This antibody is predicted to react with bovine, human, mouse, non-human primate and zebrafish based on 100% sequence homology.
This antibody is specific for ~95 kDa PSD-95 protein.
靶标信息
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: discs large homolog 4; Disks large homolog 4; FLJ97752; FLJ98574; post synaptic density; Postsynaptic density protein 95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; SAP-90; Synapse-associated protein 90; synapse-associated protein SAP90
基因别名: Dlg4; Dlgh4; PSD-95; PSD95; SAP90; SAP90A
UniProt ID: (Rat) P31016, (Mouse) Q5NCV6
Entrez Gene ID: (Rat) 29495, (Mouse) 13385
guanylate kinase activity
receptor binding
protein binding
protein C-terminus binding
protein kinase binding
protein phosphatase binding
PDZ domain binding
beta-1 adrenergic receptor binding
D1 dopamine receptor binding
P2Y1 nucleotide receptor binding
protein complex binding
acetylcholine receptor binding
glutamate receptor binding
ionotropic glutamate receptor binding
scaffold protein binding
structural molecule activity
kinase binding
neurexin family protein binding
neuroligin family protein binding
scaffold/adaptor protein
negative regulation of receptor internalization
protein complex assembly
positive regulation of cytosolic calcium ion concentration
synaptic vesicle maturation
social behavior
protein localization to synapse
locomotory exploration behavior
neuronal ion channel clustering
establishment of protein localization
establishment or maintenance of epithelial cell apical/basal polarity
nucleotide phosphorylation
regulation of long-term neuronal synaptic plasticity
positive regulation of synaptic transmission
neuromuscular process controlling balance
dendritic spine morphogenesis
vocalization behavior
AMPA glutamate receptor clustering
receptor localization to synapse
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
regulation of grooming behavior
signal transduction
chemical synaptic transmission
nervous system development
locomotory behavior
response to cocaine
regulation of neuronal synaptic plasticity
