Invitrogen

PSEN2 Polyclonal Antibody

查看其他15个PSEN2抗体

抗体检测数据 (2)

PSEN2 Antibody in Immunocytochemistry (ICC/IF)

PSEN2 Antibody in Immunocytochemistry (ICC/IF)

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PSEN2 Antibody (PA5-96774) in ICC/IF

Immunofluorescence analysis of PSEN2 in HeLa cells. Samples were incubated with PSEN2 Polyclonal antibody (Product # PA5-96774) using a dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

PSEN2 Antibody in Immunocytochemistry (ICC/IF)

PSEN2 Antibody in Western Blot (WB)

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PSEN2 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescence analysis of PSEN2 in HeLa cells. Samples were incubated with PSEN2 Polyclonal antibody (Product # PA5-96774) using a dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

PSEN2 Antibody in Western Blot (WB) — Western blot analysis of PSEN2 in extracts of various cell lines. Samples were incubated with PSEN2 Polyclonal antibody (Product # PA5-96774) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

产品信息

PA5-96774

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

-

免疫细胞化学 (ICC/IF)

1:50-1:200

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 267-384 of human PSEN2 (NP_0004382)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.65 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2808576

产品详细信息

Positive Samples: A-549, Human placenta, HepG2, HeLa, Mouse liver, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein

Immunogen sequence: VLCPKGPLRM LVETAQERNE PIFPALIYSS AMVWTVGMAK LDPSSQGALQ LPYDPEMEED SYDSFGEPSY PEVFEPPLTG YPGEELEEEE ERGVKLGLGD FIFYSVLVGK AAATGSGD

靶标信息

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: AD3LP; AD5; Alzheimer disease 4; E5-1; Presenilin-2; PS-2; PSEN 2; STM-2

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基因别名: AD3L; AD4; Ad4h; ALG-3; Alg3; CMD1V; PS-2; PS2; PSEN2; PSNL2; STM2

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UniProt ID: (Human) P49810, (Rat) O88777, (Mouse) Q61144

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Entrez Gene ID: (Human) 5664, (Rat) 81751, (Mouse) 19165

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endopeptidase activity aspartic-type endopeptidase activity protein binding molecular_function peptidase activity hydrolase activity aspartic endopeptidase activity, intramembrane cleaving aspartic protease

参与通路

response to hypoxia membrane protein ectodomain proteolysis calcium ion transport Notch signaling pathway Notch receptor processing protein processing membrane protein intracellular domain proteolysis intracellular signal transduction amyloid precursor protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of catalytic activity ephrin receptor signaling pathway beta-amyloid metabolic process negative regulation of transcription from RNA polymerase II promoter cell fate specification somitogenesis positive regulation of receptor recycling negative regulation of protein phosphorylation hair follicle development hematopoietic progenitor cell differentiation T cell activation involved in immune response myeloid leukocyte differentiation proteolysis negative regulation of epidermal growth factor-activated receptor activity regulation of epidermal growth factor-activated receptor activity learning or memory memory protein transport dorsal/ventral neural tube patterning embryonic limb morphogenesis forebrain development negative regulation of protein complex assembly negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process endoplasmic reticulum calcium ion homeostasis locomotion regulation of protein binding skin morphogenesis cellular protein metabolic process regulation of synaptic plasticity lung alveolus development thymus development brain morphogenesis positive regulation of coagulation T cell receptor signaling pathway negative regulation of ubiquitin-protein transferase activity protein maturation cardiac muscle contraction negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic signaling pathway embryo development anagen