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产品信息
H00005716-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PSMD10 (NP_002805.1, 1 a.a. approximately 226 a.a) full-length human protein.
偶联物
Unconjugated
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG
靶标信息
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.
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生物信息学
蛋白别名: 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; ankyrin repeat protein; Gankyrin; hepatocellular carcinoma-associated protein p28-II; p28(GANK); proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
基因别名: dJ889N15.2; p28; p28(GANK); PSMD10
UniProt ID: (Human) O75832
Entrez Gene ID: (Human) 5716
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
apoptotic process
cytoplasmic sequestering of NF-kappaB
positive regulation of cell growth
anaphase-promoting complex-dependent catabolic process
positive regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of MAPK cascade
regulation of mRNA stability
negative regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of cyclin-dependent protein serine/threonine kinase activity
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
proteasome regulatory particle assembly
negative regulation of canonical Wnt signaling pathway
negative regulation of release of cytochrome c from mitochondria
positive regulation of canonical Wnt signaling pathway
