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产品信息
11412-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PSMD12 Fusion Protein Ag1957 (1-320 aa encoded by BC019062)
偶联物
Unconjugated
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MADGGSERA DGRIVKMEVD YSATVDQRLP ECAKLAKEGR LQEVIETLLS LEKQTRTASD MVSTSRILVA VVKMCYEAKE WDLLNENIML LSKRRSQLKQ AVAKMVQQCC TYVEEITDLP IKLRLIDTLR MVTEGKIYVE IERARLTKTL ATIKEQNGDV KEAASILQEL QVETYGSMEK KERVEFILEQ MRLCLAVKDY IRTQIISKKI NTKFFQEENT EKLKLKYYNL MIQLDQHEGS YLSICKHYRA IYDTPCIQAE SEKWQQALKS VVLYVILAPF DNEQSDLVHR ISGDKKLEEI PKYKDLLKLF TTMELMRWST L (1-320 aa encoded by BC019062)
靶标信息
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5; MGC75406; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; proteasome 26S non-ATPase subunit 12; proteasome 26S subunit non-ATPase 12
基因别名: 1500002F15Rik; AI480719; P55; PSMD12; Rpn5
UniProt ID: (Human) O00232, (Mouse) Q9D8W5
Entrez Gene ID: (Human) 5718, (Mouse) 66997, (Rat) 287772
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
