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Bethyl Laboratories
PTEN Polyclonal Antibody
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PTEN Antibody (A300-700A) in IP
Detection of human PTEN by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-PTEN antibody BL2790 (Cat. No. A300-700A) used for immunoprecipitation at 3 µg/mg lysate. PTEN was also immunoprecipitated by rabbit anti-PTEN antibodies BL2788 (Cat. No. A300-699A) BL2789 and BL2791 (Cat. No. A300-701A). For blotting immunoprecipitated PTEN, BL2791 was used at 1 µg/ml. Detection: Chemiluminescence with an exposure ti... View More
产品信息
A300-700A
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Between 325 and 375
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse and Dog
靶标信息
PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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