Invitrogen

PTGDS Polyclonal Antibody

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PTGDS Antibody (PA1-46022) in WB

Western blot analysis of PTGDS in 0.5 mg/mL Human Brain lysate. Samples were incubated in PTGDS polyclonal antibody (Product # PA1-46022). This experiment was performed under reducing conditions using the 12-230 kDa separation system.

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产品信息

PA1-46022

应用

建议稀释比

已发表文章

免疫印迹 (WB)

2 µg/mL

产品规格

种属反应

Bovine, Horse, Cat, Fish, Human, Mouse, Non-human primate, Pig, Rabbit, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide made to a region within residues 25-100 of the human PTGDS protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 30% glycerol

内含物

0.1% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2174502

产品详细信息

This antibody has an 87% sequence homology with ovine and a 82% homology with rabbit.

Suggested positive control: antigen standard for PTGDS (transient overexpression lysate), human brain protein.

靶标信息

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer's disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Beta-trace protein; Cerebrin-28; Glutathione-independent PGD synthase; glutathione-independent PGD synthetase; L-PGDS; lipocalin-type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; PGD2 synthase; PGDS; PGDS2; Prostaglandin D synthase; prostaglandin D2 synthase (21 kDa, brain); prostaglandin D2 synthase 21kDa (brain); Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; testis tissue sperm-binding protein Li 63n

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基因别名: 21kDa; L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2; PH2DISO; PTGDS; Ptgs3