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PTGS1 Antibody (H00005742-D01P) in WB
Western Blot analysis of PTGS1 expression in transfected 293T cell line (H00005742-T01) by PTGS1 MaxPab polyclonal antibody.
Lane 1: PTGS1 transfected lysate(68.70 KDa).
Lane 2: Non-transfected lysate.
Lane 1: PTGS1 transfected lysate(68.70 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00005742-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PTGS1 (AAH29840.1, 1 a.a. approximately 599 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MSRSLLLRFL LFLLLLPPLP VLLADPGAPT PVNPCCYYPC QHQGICVRFG LDRYQCDCTR TGYSGPNCTI PGLWTWLRNS LRPSPSFTHF LLTHGRWFWE FVNATFIREM LMRLVLTVRS NLIPSPPTYN SAHDYISWES FSNVSYYTRI LPSVPKDCPT PMGTKGKKQL PDAQLLARRF LLRRKFIPDP QGTNLMFAFF AQHFTHQFFK TSGKMGPGFT KALGHGVDLG HIYGDNLERQ YQLRLFKDGK LKYQVLDGEM YPPSVEEAPV LMHYPRGIPP QSQMAVGQEV FGLLPGLMLY ATLWLREHNR VCDLLKAEHP TWGDEQLFQT TRLILIGETI KIVIEEYVQQ LSGYFLQLKF DPELLFGVQF QYRNRIAMEF NHLYHWHPLM PDSFKVGSQE YSYEQFLFNT SMLVDYGVEA LVDAFSRQIA GRIGGGRNMD HHILHVAVDV IRESREMRLQ PFNEYRKRFG MKPYTSFQEL VGEKEMAAEL EELYGDIDAL EFYPGLLLEK CHPNSIFGES MIEIGAPFSL KGLLGNPICS PEYWKPSTFG GEVGFNIVKT ATLKKLVCLN TKTCPYVSFR VPDASQDDGP AVERPSTEL
靶标信息
PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: COX-1; Cyclooxygenase-1; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; P PGG/HS; PGH synthase 1; Prostaglandin G/H synthase 1; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
基因别名: COI; Cox-1; Cox-3; COX1; COX3; COXI; MT-CO1; MTCO1; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS 1; PHS1; PTGHS; PTGS1
UniProt ID: (Human) P23219, (Mouse) P22437
Entrez Gene ID: (Human) 5742, (Mouse) 19224
prostaglandin biosynthetic process
lipid metabolic process
xenobiotic metabolic process
inflammatory response
response to oxidative stress
aging
learning
memory
regulation of blood pressure
response to organonitrogen compound
negative regulation of norepinephrine secretion
sensory perception of pain
cyclooxygenase pathway
negative regulation of epinephrine secretion
maintenance of blood-brain barrier
regulation of cell proliferation
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
response to corticosterone
oxidation-reduction process
response to fatty acid
cellular oxidant detoxification
fatty acid metabolic process
fatty acid biosynthetic process
prostaglandin metabolic process
keratinocyte differentiation
