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产品信息
67346-1-IG
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
1F12G7
抗原
PTGS1 Fusion Protein Ag28280
偶联物
形式
Liquid
浓度
1000 µg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Aliquoting is unnecessary for -20°C storage.
靶标信息
PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.
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生物信息学
蛋白别名: COX-1; Cyclooxygenase-1; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; P PGG/HS; PGH synthase 1; Prostaglandin G/H synthase 1; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
基因别名: COI; COX1; COX3; COXI; MT-CO1; MTCO1; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS; PTGS1
UniProt ID: (Human) P23219
Entrez Gene ID: (Human) 5742
prostaglandin biosynthetic process
lipid metabolic process
xenobiotic metabolic process
inflammatory response
response to oxidative stress
aging
learning
memory
regulation of blood pressure
response to organonitrogen compound
negative regulation of norepinephrine secretion
sensory perception of pain
cyclooxygenase pathway
negative regulation of epinephrine secretion
maintenance of blood-brain barrier
regulation of cell proliferation
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
response to corticosterone
oxidation-reduction process
response to fatty acid
cellular oxidant detoxification
