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Additional Information: This antibody is expected to recognize both reported isoforms (NP_001092755.1; NP_002814.3).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:1,000.
The thymus gland produces several hormones or hormone-like substances which are derived from a polypeptide precursor containing (in the rat) 113 amino acids and known as prothymosin-alpha. A peptide containing 28 amino acid residues, named thymosin-alpha-1, was originally isolated from calf thymosin fraction 5 and shown to restore various aspects of immune function in several in vitro and invivo test systems. Thymosin-alpha-1 was subsequently isolated from a similar fraction from human thymosin and reported to have the same amino acid sequence as bovine thymosin-alpha-1. In 2003, Jiang et al. identified a pathway that regulates mitochondria-initiated caspase activity. In this pathway, putative human HLA class II-associated protein (PHAP) promoted caspase-9 activation after apoptosome formation, whereas prothymosin-alpha-1 negatively regulated caspase-9 activation by inhibiting apoptosome formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: gene sequence 28; Prothymosin alpha; prothymosin alpha protein; thymosin; TMSB4; TMSB4X
基因别名: PTMA; TMSA
UniProt ID: (Human) P06454
Entrez Gene ID: (Human) 5757