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产品信息
PA5-120608
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human PTPN2 (NP_536348.1).
偶联物
形式
Liquid
浓度
2.48 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914180
产品详细信息
Positive test controls include: SW480, BT-474, Jurkat, K-562. The target is usually found in the following locations: Cell membrane, Cytoplasm, Endoplasmic reticulum, Endoplasmic reticulum-Golgi intermediate compartment, Nucleus.
Immunogen sequence: MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV KSYYTVHLLQ LENINSGETR TISHFHYTTW PDFGVPESPA SFLNFLFKVR ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSERPRL TDT
靶标信息
T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations. The shorter 45 kilodalton isoform is exclusively nuclear in resting cells, but redistrubutes to the cytosol upon stimulation with growth factors and cellular stress. The longer 48 kilodalton isoform is exclusively found in the endoplasmic reticulum 3 and seems to have distinctly different physiologic substrates from the smaller isoform. Although found in many cell types and tissues, TC-PTP is particularly prominent in hemopoietic cell types. Knockout mice lacking TC-PTP are born viable but die 3 to 5 weeks after birth of erythropoietic and lymphopoietic deficits 7, indicating a critical role for TC-PTP in bone marrow maturation. TC-PTP will dephosphorylate a wide range of phosphoproteins, such as p52 Shc 6 and receptors for EGF 1, Insulin 8 and growth hormone.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MPTP; Protein-tyrosine phosphatase PTP-2; Protein-tyrosine phosphatase PTP-S; PTPN 2; T cell protein-tyrosine phosphatase; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TC PTP; TCPTP; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 2
基因别名: AI325124; PTN2; PTPN2; PTPT; TC-PTP; TCELLPTP; TCPTP
UniProt ID: (Human) P17706, (Mouse) Q06180, (Rat) P35233
Entrez Gene ID: (Human) 5771, (Mouse) 19255, (Rat) 117063
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
integrin binding
protein binding
protein kinase binding
syntaxin binding
receptor tyrosine kinase binding
phosphoprotein phosphatase activity
hydrolase activity
phosphatase activity
DNA binding
protein phosphatase
negative regulation of cell proliferation
insulin receptor signaling pathway
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of lipid storage
B cell differentiation
T cell differentiation
erythrocyte differentiation
peptidyl-tyrosine dephosphorylation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of tyrosine phosphorylation of Stat1 protein
negative regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of tyrosine phosphorylation of Stat6 protein
glucose homeostasis
negative regulation of macrophage differentiation
positive regulation of gluconeogenesis
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
negative regulation of T cell receptor signaling pathway
negative regulation of chemotaxis
regulation of interferon-gamma-mediated signaling pathway
negative regulation of interferon-gamma-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
negative regulation of protein tyrosine kinase activity
negative regulation of interleukin-6-mediated signaling pathway
negative regulation of ERK1 and ERK2 cascade
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of interleukin-2-mediated signaling pathway
negative regulation of prolactin signaling pathway
negative regulation of interleukin-4-mediated signaling pathway
negative regulation of macrophage colony-stimulating factor signaling pathway
negative regulation of positive thymic T cell selection
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of PERK-mediated unfolded protein response
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
protein dephosphorylation
dephosphorylation
negative regulation of tyrosine phosphorylation of Stat3 protein
