Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
H00009232-M23
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3H8
抗原
PTTG1 (NP_004210, 93 a.a. approximately 113 a.a) synthetic peptide.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Immunogen sequence: CKTVKAKSSV PASD
靶标信息
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Esp1-associated protein; ESP1-associated protein 1; MGC126883; MGC138276; Pituitary tumor-transforming gene 1 protein; Securin; Tumor-transforming protein 1
基因别名: EAP1; HPTTG; PTTG; PTTG1; TUTR1
UniProt ID: (Human) O95997
Entrez Gene ID: (Human) 9232
DNA repair
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
mitotic nuclear division
spermatogenesis
negative regulation of endopeptidase activity
anaphase-promoting complex-dependent catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
homologous chromosome segregation
chromosome organization
cell division
