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PTX3 Antibody (PA5-101097) in ICC/IF
Immunocytochemistry analysis of PTX3 in A549 cells (H2O2 treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with PTX3 polyclonal antibody (Product # PA5-101097) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-101097
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PTX3(Accession P26022), corresponding to amino acid residues L7-D57.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850541
产品详细信息
Antibody detects endogenous levels of total PTX3.
靶标信息
Pentraxins are a protein superfamily that is characterized by a cyclic multimeric structure. Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents. Ptx3 belongs to the family of "long pentraxins", which have C-terminal pentraxin domains and novel amino-terminal domains. Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion of Ptx3 in adipose cells can be induced by TNF. Ptx3 is also involved in amplification of inflammatory reactions and regulation of innate immunity. The human PTX3 gene maps to chromosome 3q25.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: long pentraxin 3; pentaxin related; Pentaxin-related protein PTX3; pentraxin 3; Pentraxin-related protein PTX3; TNF alpha-induced protein 5; TSG-14; Tumor necrosis factor alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; tumor necrosis factor-inducible protein TSG-14
基因别名: AI607804; PTX3; TNFAIP5; TSG-14; TSG14
UniProt ID: (Human) Q38M82, (Mouse) P48759
Entrez Gene ID: (Human) 5806, (Mouse) 19288
response to yeast
inflammatory response
opsonization
negative regulation by host of viral exo-alpha-sialidase activity
negative regulation by host of viral glycoprotein metabolic process
innate immune response
positive regulation of nitric oxide biosynthetic process
negative regulation of viral entry into host cell
positive regulation of phagocytosis
negative regulation of exo-alpha-sialidase activity
negative regulation of glycoprotein metabolic process
