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Peptide sequence: EIIVKIFVEF SIASETHKAI QALNGRWFAG RKVVAEVYDQ ERFDNSDLSA
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100%
PUF60 encodes a protein that is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 60 kDa poly(U)-binding-splicing factor; FBP interacting repressor; FBP-interacting repressor; FLJ31379; FUSE-binding protein-interacting repressor; poly(U) binding splicing factor 60KDa; Poly(U)-binding-splicing factor PUF60; poly-U binding splicing factor 60KDa; pyrimidine tract binding splicing factor; Ro ribonucleoprotein-binding protein 1; Ro-binding protein 1; RoBP1; Siah binding protein 1; Siah-binding protein 1; Siah-BP1
基因别名: FIR; PUF60; ROBPI; SIAHBP1; VRJS
UniProt ID: (Human) Q9UHX1
Entrez Gene ID: (Human) 22827