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Sequence of this protein is as follows: GAGGNKSRLT LSMSVAVEFR DYLGDFIEHY AQLGPSQPPD LAQAQDEPRR
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: purine-rich element binding protein A; Purine-rich single-stranded DNA-binding protein alpha; Transcriptional activator protein Pur-alpha
基因别名: MRD31; PUR-ALPHA; PUR1; PURA; PURALPHA
UniProt ID: (Human) Q00577
Entrez Gene ID: (Human) 5813