NeoBiotechnologies

Pan-Cadherin Monoclonal Antibody (Pan-CAD/8020)

Pan-Cadherin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Pan-Cadherin Antibody (MSM2-8020-P1ABX) in IHC (P)

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Pan-Cadherin Mouse Monoclonal Antibody (Pan-CAD/8020). Inset: PBS instead of primary antibody; secondary only negative control.

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产品信息

MSM2-8020-P1ABX

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

Pan-CAD/8020

抗原

Recombinant fragment of human C-terminal of Pan-Cadherin.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS

内含物

no preservative

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Dry ice (international)

产品详细信息

Positive Control: colon Human heart prostate or brain.

Cellular Location: Cell junction.

靶标信息

Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, type 1, P-cadherin (placental); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin e; Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; cadherin-E; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; CDw325; CDw325 antigen; cell-CAM 120/80; E-Cadherin; E-cadherin 1; Epithelial cadherin; N-cadherin; N-cadherin 1; Neural cadherin; P-cadherin; Pan Cadherin; Placental cadherin; Placental-cadherin; R-CAD; R-cadherin; Retinal cadherin; Uvomorulin

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基因别名: Arc-1; CAD4; CD324; CD325; CDH1; CDH2; CDH3; CDH4; CDHE; CDHN; CDHP; CDw325; ECAD; HJMD; LCAM; NCAD; PCAD; R-CAD; RCAD; UVO