Proteintech

Periostin Monoclonal Antibody (1A11A3)

Periostin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 9

Periostin Antibody (66491-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue slide using (Product # 66491-1-Ig) Periostin antibody at dilution of 1:8,000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Periostin Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

产品信息

66491-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2500-1:10,000

查看5篇已发表文章 5篇已发表文章

免疫组化 (IHC)

查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:250-1:1,000

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:8,000

免疫细胞化学 (ICC/IF)

查看3篇已发表文章 3篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

1A11A3

抗原

Periostin Fusion Protein Ag14487 (21-368 aa encoded by BC106710)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: ANNHYDKIL AHSRIRGRDQ GPNVCALQQI LGTKKKYFST CKNWYKKSIC GQKTTVLYEC CPGYMRMEGM KGCPAVLPID HVYGTLGIVG ATTTQRYSDA SKLREEIEGK GSFTYFAPSN EAWDNLDSDI RRGLESNVNV ELLNALHSHM INKRMLTKDL KNGMIIPSMY NNLGLFINHY PNGVVTVNCA RIIHGNQIAT NGVVHVIDRV LTQIGTSIQD FIEAEDDLSS FRAAAITSDI LEALGRDGHF TLFAPTNEAF EKLPRGVLER IMGDKVASEA LMKYHILNTL QCSESIMGGA VFETLEGNTI EIGCDGDSIT VNGIKMVNKK DIVTNNGVIH LIDQVLIPD (21-368 aa encoded by BC106710)

靶标信息

Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

SPARC in cancer-associated fibroblasts is an independent poor prognostic factor in non-metastatic triple-negative breast cancer and exhibits pro-tumor activity.

International journal of cancer

Alcaraz LB,Mallavialle A,Mollevi C,Boissière-Michot F,Mansouri H,Simony-Lafontaine J,Laurent-Matha V,Chardès T,Jacot W,Turtoi A,Roger P,Guiu S,Liaudet-Coopman E

Wed Mar 15 00:00:00 EDT 2023

Ciclopirox Inhibition of eIF5A Hypusination Attenuates Fibroblast Activation and Cardiac Fibrosis.

Journal of cardiovascular development and disease

Subbaiah KCV,Wu J,Tang WHW,Yao P

Sun Jan 29 00:00:00 EST 2023

Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single-Cell Resolution.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhou T,Chen Y,Liao Z,Zhang L,Su D,Li Z,Yang X,Ke X,Liu H,Chen Y,Weng R,Shen H,Xu C,Wan Y,Xu R,Su P

Mon May 01 00:00:00 EDT 2023

Bioinformatics analysis and identification of dysregulated POSTN in the pathogenesis of keloid.

International wound journal

Xu H,Wang Z,Yang H,Zhu J,Hu Z

Mon May 01 00:00:00 EDT 2023

Micro/nano-topography promotes osteogenic differentiation of bone marrow stem cells by regulating periostin expression.

Colloids and surfaces. B, Biointerfaces

Li J,Hou W,Yang Y,Deng Q,Fu H,Yin Y,Duan K,Feng B,Guo T,Weng J

Sat Oct 01 00:00:00 EDT 2022

Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration.

Molecular therapy : the journal of the American Society of Gene Therapy

Wu J,Chen Y,Liao Z,Liu H,Zhang S,Zhong D,Qiu X,Chen T,Su D,Ke X,Wan Y,Zhou T,Su P

Wed Oct 05 00:00:00 EDT 2022

Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration.

Molecular therapy : the journal of the American Society of Gene Therapy

Wu J,Chen Y,Liao Z,Liu H,Zhang S,Zhong D,Qiu X,Chen T,Su D,Ke X,Wan Y,Zhou T,Su P

Wed Oct 05 00:00:00 EDT 2022

Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway.

Cancer cell international

Xu C,Wang Z,Zhang L,Feng Y,Lv J,Wu Z,Yang R,Wu T,Li J,Zhou R,Tian Z,Bai J,Zhang H,Lan Y,Lv Z

Thu Jan 20 00:00:00 EST 2022

Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway.

Cancer cell international

Xu C,Wang Z,Zhang L,Feng Y,Lv J,Wu Z,Yang R,Wu T,Li J,Zhou R,Tian Z,Bai J,Zhang H,Lan Y,Lv Z

Thu Jan 20 00:00:00 EST 2022

Changed PGA and POSTN levels in choroid plexus are associated with depressive-like behaviors in mice.

Biochemical and biophysical research communications

Liu J,He Y,Cheng K,Xie P

Thu Mar 26 00:00:00 EDT 2020

Periostin Mediates Right Ventricular Failure through Induction of Inducible Nitric Oxide Synthase Expression in Right Ventricular Fibroblasts from Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats.

International journal of molecular sciences

Imoto K,Okada M,Yamawaki H

Mon Dec 24 00:00:00 EST 2018

International journal of molecular sciences

Imoto K,Okada M,Yamawaki H

Mon Dec 24 00:00:00 EST 2018

生物信息学

蛋白别名: fasciclin I-like; Fasciclin-I like; MGC119510; MGC119511; OSF 2; OSF-2; osteoblast specific factor 2; osteoblast specific factor 2 (fasciclin I-like); Osteoblast-specific factor 2; periodontal ligament-specific periostin; Periostin; periostin, osteoblast specific factor; periostin-like factor; PN; RP11 412K4.1; RP11-412K4.1

查看更多收起

基因别名: A630052E07Rik; AI747096; OSF-2; OSF2; PDLPOSTN; peri; PLF; PN; POSTN

查看更多收起

UniProt ID: (Human) Q15063, (Mouse) Q62009

查看更多收起

Entrez Gene ID: (Human) 10631, (Rat) 361945, (Mouse) 50706

查看更多收起

功能

protein binding heparin binding metal ion binding cell adhesion molecule binding cell adhesion molecule

参与通路