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NeoBiotechnologies
Periostin (POSTN) Recombinant Rabbit Monoclonal Antibody (POSTN/8951R)
产品信息
10631-RBM13-P1
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
POSTN/8951R
抗原
Recombinant fragment of human POSTN protein (exact sequence is proprietary)
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control: breast or colon tissue. Human placenta
Cellular Location: Secreted. Extracellular space. Extracellular matrix.
靶标信息
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: fasciclin I-like; Fasciclin-I like; MGC119510; MGC119511; OSF 2; OSF-2; osteoblast specific factor 2; osteoblast specific factor 2 (fasciclin I-like); Osteoblast-specific factor 2; periodontal ligament-specific periostin; Periostin; periostin, osteoblast specific factor; PN; RP11 412K4.1; RP11-412K4.1
基因别名: OSF-2; OSF2; PDLPOSTN; PN; POSTN
UniProt ID: (Human) Q15063
Entrez Gene ID: (Human) 10631
skeletal system development
response to hypoxia
negative regulation of cell-matrix adhesion
regulation of systemic arterial blood pressure
cell adhesion
regulation of Notch signaling pathway
response to mechanical stimulus
response to muscle activity
positive regulation of smooth muscle cell migration
extracellular matrix organization
response to estradiol
cellular response to fibroblast growth factor stimulus
cellular response to vitamin K
cellular response to tumor necrosis factor
cellular response to transforming growth factor beta stimulus
negative regulation of substrate adhesion-dependent cell spreading
positive regulation of chemokine (C-C motif) ligand 2 secretion
neuron projection extension
bone regeneration
