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Phospho-4EBP1 (Ser65) Antibody (MA5-14948) in WB
Western blot analysis of Phospho-4E-BP1 pSer65 in extracts from 293 cells, lambda phosphatase-treated or treated with 20% FBS, using Phospho-4E-BP1 pSer65 monoclonal antibody (Product # MA5-14948) (upper) or a 4E-BP1 polyclonal antibody (lower).
产品信息
MA5-14948
产品规格
种属反应
Human,
Mouse,
Non-human primate
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
T.730.9
抗原
Synthetic phosphopeptide corresponding to residues surrounding pSer65 of mouse 4E-BP1
偶联物
形式
Liquid
浓度
156.5 µg/mL
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
<0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_10978119
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 4E-BP1; eIF4E-binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; MGC431; MGC4316; P/OKCL.6; PHAS-1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1
基因别名: 4E-BP1; 4EBP1; AA959816; BP-1; EIF4EBP1; PHAS-I
UniProt ID: (Human) Q13541, (Mouse) Q60876
Entrez Gene ID: (Human) 1978, (Mouse) 13685
G1/S transition of mitotic cell cycle
IRES-dependent translational initiation
response to ischemia
insulin receptor signaling pathway
lung development
negative regulation of protein complex assembly
TOR signaling
response to ethanol
positive regulation of mitotic cell cycle
negative regulation of translational initiation
cellular response to hypoxia
regulation of translation
regulation of translational initiation
negative regulation of translation
