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Invitrogen
Phospho-Ask1 (Ser83) Recombinant Rabbit Monoclonal Antibody (Ask1S83-G4), FITC
图: 1 / 1
Phospho-Ask1 (Ser83) Antibody (MA5-36975) in Flow
Flow cytometry of Phospho-Ask1 (Ser83) using HT1080 cells. Samples were incubated in monoclonal Phospho-Ask1 (Ser83) antibody (Product # MA5-36975). Images correspond with the following conditions: negative control (blue), treated with imatinib (red), with pervanadate (green).
产品信息
MA5-36975
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
Ask1S83-G4
抗原
A synthetic phospho-peptide corresponding to residues surrounding Ser83 of human phospho Ask1.
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
纯化类型
Protein A/G
保存液
PBS with 0.20% BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2896910
靶标信息
MAP3K5 (ASK1) is a serine/threonine kinase that is abundantly expressed in human heart and pancreas and are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: apoptosis signal regulating kinase 1; Apoptosis signal-regulating kinase 1; ASK 1; ASK-1; EC 2.7.11.25; kinase ASK1; M3K5; MAP/ERK kinase kinase 5; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5; mitogen activated protein kinase kinase kinase 5; Mitogen-activated protein kinase kinase kinase 5; RP3-325F22.4
基因别名: 7420452D20Rik; ASK; ASK1; MAP3K5; MAPKKK5; MEKK5; RGD1306565
UniProt ID: (Human) Q99683, (Mouse) O35099
Entrez Gene ID: (Human) 4217, (Mouse) 26408, (Rat) 365057
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
protein kinase binding
protein phosphatase binding
protein homodimerization activity
nucleotide binding
cysteine-type endopeptidase activator activity involved in apoptotic process
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPKK activity
response to ischemia
protein phosphorylation
JNK cascade
activation of JUN kinase activity
intrinsic apoptotic signaling pathway in response to oxidative stress
viral process
response to endoplasmic reticulum stress
p38MAPK cascade
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of JUN kinase activity
innate immune response
positive regulation of myoblast differentiation
positive regulation of JNK cascade
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to hydrogen peroxide
apoptotic signaling pathway
programmed necrotic cell death
positive regulation of neuron death
cellular response to reactive nitrogen species
activation of MAPK activity
positive regulation of protein phosphorylation
immune system process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cell death
phosphorylation
