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Phospho-BAD (Ser112) Antibody (MA5-37058) in Flow
Flow cytometry of Phospho-BAD (Ser112) using U937 cells. Samples were incubated in monoclonal Phospho-BAD (Ser112) antibody (Product # MA5-37058) with a dilution of 0.1 µg/mL. Images correspond with the following conditions: negative control (blue), Calyculin A-treated (green), CalA and blocked with phospho peptide (gold), CalA and blocked with non-phospho peptide (purple).
产品信息
MA5-37058
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BADS112-B9
抗原
A synthetic phospho-peptide corresponding to residues surrounding Ser112 of human phospho BAD.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2896993
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
The protein encoded by BAD is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BAD; bcl-2 associated death agonist; Bcl-2-binding component 6; Bcl-2-like protein 8; BCL-X/BCL-2 binding protein; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; Bcl2-antagonist of cell death; BCL2-antagonist of cell death protein; BCL2-associated agonist of cell death; bcl2-associated death promoter; BCL2-binding component 6; BCL2-binding protein; Bcl2-L-8; OTTMUSP00000017561; OTTMUSP00000022400
基因别名: AI325008; BAD; BBC2; BBC6; BCL2L8
UniProt ID: (Human) Q92934, (Mouse) Q61337, (Rat) O35147
Entrez Gene ID: (Human) 572, (Mouse) 12015, (Rat) 64639
release of cytochrome c from mitochondria
glucose catabolic process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of mitochondrial membrane potential
suppression by virus of host apoptotic process
cytokine-mediated signaling pathway
positive regulation of insulin secretion
positive regulation of glucokinase activity
positive regulation of insulin secretion involved in cellular response to glucose stimulus
glucose homeostasis
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
type B pancreatic cell proliferation
positive regulation of B cell differentiation
positive regulation of T cell differentiation
positive regulation of proteolysis
negative regulation of cytolysis
ADP metabolic process
ATP metabolic process
regulation of mitochondrial membrane permeability
pore complex assembly
positive regulation of epithelial cell proliferation
positive regulation of apoptotic process by virus
cellular process regulating host cell cycle in response to virus
cellular response to organic substance
cellular response to nicotine
positive regulation of release of cytochrome c from mitochondria
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
intrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity
positive regulation of neuron death
positive regulation of type B pancreatic cell development
response to hypoxia
response to hormone
response to glucose
response to organic substance
response to organic cyclic compound
response to estradiol
response to progesterone
response to testosterone
response to oleic acid
response to drug
response to hydrogen peroxide
response to amino acid
response to ethanol
response to glucocorticoid
response to calcium ion
cellular response to chromate
cellular response to mechanical stimulus
cellular response to lipid
cellular response to hypoxia
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
spermatogenesis
positive regulation of autophagy
cerebral cortex development
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
