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Phospho-BRCA2 (Ser2095) Antibody (PA5-105585) in ICC/IF
Immunocytochemistry analysis of Phospho-BRCA2 (Ser2095) in HepG2 cells (4h of LPS treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-BRCA2 (Ser2095) polyclonal antibody (Product # PA5-105585) 1:200 and mouse anti-beta tubulin antibody (1:200) for 1 hour at 37°C. An AlexaFluor594 conjugated ... View More
产品信息
PA5-105585
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human BRCA2(Accession P51587), corresponding to amino acid residues around phosphorylated Ser2095.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2817013
产品详细信息
Antibody detects endogenous levels of BRCA2 only when phosphorylated at Ser2095.
靶标信息
Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumor-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brca 2; brca-2; BRCA1/BRCA2-containing complex, subunit 2; breast and ovarian cancer susceptibility gene, early onset; breast and ovarian cancer susceptibility protein 2; breast cancer 2 tumor suppressor; breast cancer 2, early onset; breast cancer 2, mutation 1, University of Wisconsin-Madison; breast cancer susceptibility protein 2; Breast cancer type 2 susceptibility protein; Breast cancer type 2 susceptibility protein homolog; FANCB; Fanconi anemia group D1 protein; Fanconi anemia group D1 protein homolog; mutant BRCA2; RP11-298P3.4
基因别名: BRCA2; BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; RAB163; XRCC11
UniProt ID: (Human) P51587, (Mouse) P97929
Entrez Gene ID: (Human) 675, (Mouse) 12190, (Rat) 360254
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA synthesis involved in DNA repair
strand displacement
cytokinesis
oocyte maturation
inner cell mass cell proliferation
nucleotide-excision repair
double-strand break repair
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
male meiosis I
spermatogenesis
brain development
cell aging
response to nutrient
female gonad development
response to X-ray
response to UV-C
response to gamma radiation
hemopoiesis
mammary gland development
chromosome breakage
homologous chromosome orientation involved in meiotic metaphase I plate congression
response to estradiol
regulation of cytokinesis
negative regulation of mammary gland epithelial cell proliferation
multicellular organism growth
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
histone H3 acetylation
histone H4 acetylation
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
replication fork protection
centrosome duplication
establishment of protein localization to telomere
mitotic recombination-dependent replication fork processing
DNA repair
DNA recombination
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
cell cycle
cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of cell proliferation
chordate embryonic development
chromosome organization
