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Phospho-CRMP2 (Ser522) Antibody (PA5-143675) in ICC/IF
Immunocytochemistry analysis of Phospho-CRMP2 (Ser522) in aldehyde-fixed and NP-40-permeabilized NGF-differentiated PC12 cells. The cells were labeled with rabbit polyclonal anti-Phospho-CRMP2 (Ser522) polyclonal antibody (Product # PA5-143675) in the absence (Left) or presence (Right) of blocking peptide. The antibody was detected using appropriate secondary antibody conjugated to DyLight® 594.
产品信息
PA5-143675
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Phospho-CRMP2 (Ser-522) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding Ser-522 in human CRMP2. This sequence is conserved in rat and mouse CRMP2, and has homology to the conserved site in CRMP1 and CRMP4, but is not conserved in CRMP3 and CRMP5.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2942903
产品详细信息
The antibody detects a 70 kDa* protein corresponding to the molecular mass of CRMP2 on SDS-PAGE immunoblots of human mouse brain, and this band is removed after lambda phosphatase treatment. In addition, this reactivity can be specifically blocked using phospho-CRMP2 (Ser-522) peptide (CX2195).
靶标信息
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Collapsin response mediator protein 2; collapsin response mediator protein hCRMP-2; CRMP-2; dihydropyrimidinase-like 2; Dihydropyrimidinase-related protein 2; DPYL2; DRP-2; N2A3; TOAD-64; Turned on after division 64 kDa protein; turned on after division, 64 kDa protein; ULIP-2; Unc-33-like phosphoprotein 2
基因别名: AI851130; CRMP-2; CRMP2; DHPRP2; DPYSL2; DRP-2; DRP2; Musunc33; N2A3; TOAD-64; ULIP-2; ULIP2
UniProt ID: (Human) Q16555, (Rat) P47942, (Mouse) O08553
Entrez Gene ID: (Human) 1808, (Rat) 25416, (Mouse) 12934
response to amphetamine
nucleobase-containing compound metabolic process
endocytosis
cytoskeleton organization
signal transduction
nervous system development
axon guidance
positive regulation of glutamate secretion
spinal cord development
olfactory bulb development
regulation of axon extension
response to cocaine
response to drug
synaptic vesicle transport
pyrimidine nucleobase catabolic process
brain development
regulation of neuron projection development
regulation of neuron differentiation
multicellular organism development
cell differentiation
