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Invitrogen
Phospho-Chk1 (Ser317) Recombinant Rabbit Monoclonal Antibody (Chk1S317-F10), PE
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Phospho-Chk1 (Ser317) Antibody (MA5-37002) in Flow
Flow cytometry of Phospho-Chk1 (Ser317) using HeLa cells. Samples were incubated in monoclonal Phospho-Chk1 (Ser317) antibody (Product # MA5-37002). Images correspond with the following conditions: negative control (blue), treated with imatinib (red), treated with pervanadate (green).
产品信息
MA5-37002
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
Chk1S317-F10
抗原
A synthetic phospho-peptide corresponding to residues surrounding Ser317 of human phospho Chk1.
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
纯化类型
Protein A/G
保存液
PBS with 0.20% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2896937
靶标信息
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cell cycle checkpoint kinase; checkpoint kinase 1 homolog; Checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27 homolog; Serine/threonine-protein kinase Chk1
基因别名: C85740; CHEK1; CHK1; rad27
UniProt ID: (Human) O14757, (Mouse) O35280
Entrez Gene ID: (Human) 1111, (Mouse) 12649
DNA damage checkpoint
G2/M transition of mitotic cell cycle
DNA replication
DNA repair
cellular response to DNA damage stimulus
DNA damage induced protein phosphorylation
regulation of double-strand break repair via homologous recombination
regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
peptidyl-threonine phosphorylation
G2 DNA damage checkpoint
histone H3-T11 phosphorylation
regulation of cell proliferation
negative regulation of mitotic nuclear division
regulation of mitotic centrosome separation
chromatin-mediated maintenance of transcription
cellular response to mechanical stimulus
replicative senescence
regulation of signal transduction by p53 class mediator
regulation of histone H3-K9 acetylation
protein phosphorylation
cell cycle
regulation of gene expression
negative regulation of G2/M transition of mitotic cell cycle
phosphorylation
negative regulation of DNA biosynthetic process
