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产品信息
PA5-64574
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DYRK1A/B (Phospho-Tyr321/273)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2663607
产品详细信息
Phospho-DYRK1A/DYRK1B (Tyr321, 273) Polyclonal Antibody detects endogenous levels of DYRK1A/DYRK1B only when phosphorylated at Tyr321, 273.
靶标信息
DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2; this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual Specificity Yak1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; hMNB; HP86; Minibrain-related kinase; Mirk protein kinase; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; MP86; Protein kinase minibrain homolog; RP86; serine/threonine kinase MNB; serine/threonine-specific protein kinase
基因别名: 2310043O08Rik; AOMS3; D16Ertd272e; D16Ertd493e; DYRK; DYRK1; DYRK1A; DYRK1B; ENSMUSG00000074897; Gm10783; HP86; MIRK; mmb; MNB; MNBH; Mp86; MRD7; PSK47
UniProt ID: (Human) Q13627, (Human) Q9Y463, (Mouse) Q61214, (Rat) Q63470, (Mouse) Q9Z188
Entrez Gene ID: (Human) 1859, (Human) 9149, (Mouse) 13548, (Rat) 25255, (Mouse) 13549, (Rat) 308468
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
identical protein binding
protein self-association
tau protein binding
transcription coactivator activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
myoblast fusion
peptidyl-tyrosine phosphorylation
positive regulation of transcription, DNA-templated
adipose tissue development
regulation of alternative mRNA splicing, via spliceosome
circadian rhythm
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
negative regulation of DNA damage response, signal transduction by p53 class mediator
protein autophosphorylation
negative regulation of mRNA splicing, via spliceosome
positive regulation of protein deacetylation
nervous system development
regulation of endocytosis
