Invitrogen

Phospho-DYRK2/DYRK4 (Tyr382, Tyr264) Polyclonal Antibody

Phospho-DYRK2/DYRK4 (Tyr382, Tyr264) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Phospho-DYRK2/DYRK4 (Tyr382, Tyr264) Antibody (PA5-105875) in IHC (P)

Immunohistochemistry analysis of paraffin-embedded Phospho-DYRK2/DYRK4 (Tyr386, Tyr268) in rat intestinal tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-DYRK2/DYRK4 (Tyr386, Tyr268) polyclonal antibody (Product # PA5-105875) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-r... View More

Phospho-DYRK2/DYRK4 (Tyr382, Tyr264) Antibody in Western Blot (WB)

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产品信息

PA5-105875

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:3,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human DYRK2(Accession Q92630), corresponding to amino acid residues around phosphorylated Tyr382.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2817274

产品详细信息

Antibody detects endogenous levels of DYRK2/4 only when phosphorylated at Y382/Y264.

靶标信息

DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4; Dual specificity tyrosine-phosphorylation-regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 4; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4; dyrk2; dyrk4; RAD51 associated protein 1

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基因别名: 1810038L18Rik; AW049118; DYRK2; DYRK4; Dyrk4a; Dyrk4b; Rad51ap1